How effective are probiotics for acne-prone skin?

How effective are probiotics for acne-prone skin?




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You’ve probably seen that probiotics are becoming an increasingly popular ingredient in skincare products for skin problems such as adult acne. Today, we bring you the scientific conclusions that make them the new game changer for acne-prone skin.

We are so excited to share the results of our latest clinical study - but before we dive into the topic, maybe you are asking yourself what is a clinical study? No need to go to Google, we’ll explain it all!

A clinical study or clinical trial is a type of research study conducted on humans to test the effectiveness of how well new medications, therapies, or vaccine approaches work in (or on!) people, the safety, and the tolerance of the formulation.

That’s a mandatory step to commercializing a skincare product.

We have conducted 15 clinical studies to test our Living Skin Probiotics: this is our active ingredient, that you can find on the vials in your Sencyr Reset. In this blog post, we’ll share with you some results of our clinical studies. If you are still hesitating to buy, let us demonstrate how effective are probiotics for acne-prone skin.


First of all, let’s start with our latest clinical study in Portugal conducted by Inovapotek.

In this clinical study, we tested the probiotics on 62 subjects with mild to moderate acne, from 12 to 25 years old. We analyzed their skin on days 0, 7, 10, 14, 21, 38, 45, and 51 and then also analyzed it 12 days after they stop the product at day 63. Several parameters were taken into accounts such as skin microbiome, skin irritation, radiance, pores, number of spots, and sebum on the skin.

Why did we continue to analyze the skin 12 days after they stop? Sometimes, with other skincare brands, you see great results when using the product but when you stop, your pimples come back! It’s an endless circle. We wanted to be sure it would not be the case as we aim to be a long-term solution and not here to stay in your routine forever.


The results were amazing. Here are the results regarding irritation, radiance, and skin tone:

  • They saw no increase of skin irritation signs in 87% of the subjects after 44 days of use
  • No increase of skin irritation symptoms in 96% after 12 days of irruption
  • Well tolerated by people i.e no sign of allergies or irritation in general
  • Skin appears lighter after 44 days with no changes after 12 days of irruption
  • Skin tone appears more even after 44 days
  • Help reduce blemishes after 44 days with no changes after 12 days of irruption


A dermatologist also counted the number of inflammatory and non-inflammatory on different days of the program. Newtone Colorface technology was used, an expert on image proof.

Here are the results:

  • Non-inflammatory lesions were reduced in 65% of subjects after 44 days of use
  • Helps reduce blackheads and whiteheads
  • Total acne lesions reduced in 72.41% of subjects after 44 days of use
  • Dermatologists say 73% of subjects have clearer skin, less oily and shiny skin after 44 days of use and 87% have less oily and shiny skin after 12 days of irruption


We are in collaboration with Royal DSM, a global, purpose-led company in health, nutrition & bioscience, applying science to improve the health of people, animals, and the planet.

Together, we have done a clinical study to test the efficacy of our probiotic strains. This was one of the largest studies with the skin’s bacteria that has ever been conducted. We were able to achieve our defined study goals without any problems“ said Bernhard Paetzold, Chief Scientific Officer of S-Biomedic.

The results were outstanding: they showed a significant improvement in lesion counts and redness reduction. Also, there was a significant change in the skin microbiome composition. Wesley Carpentier, Chief Commercial Officer of S-Biomedic added: “This study is an important validation of our technology platform. Now, after 6 years of development, we have the first true Living Skin Probiotics probiotic coming to the market, backed by extensive clinical and safety research.”

Rishabh Pande, VP of Marketing & Innovation, Personal Care at DSM commented: ”The successful completion of this joint study marks an important milestone in our journey to bring this exciting technology to the market. We are very pleased with the positive results, which further reinforce the potential of this technology to have a positive impact on people’s lives.”


Finally, we have conducted a consumer study. What is a consumer study? This is when we test products on humans and they give their opinion on the effectiveness of the products based on their own opinion, and not involving any professional.

We conducted this test on 24 people (21 female and 3 male) from different countries in Europe, with an average of 28 years old. They all had combination skin, with an average acne severity of 5.9/10. They used Sencyr Reset for 30 days. On Day 15, 54% of people saw improvement since day 1. They already had a feeling of skin softer, healthier, stronger, and smoother. Pores were less visible, skin with less redness, and no new pimples appeared. They have seen a decrease of 20% in black spots. On day 30, 60% of people saw improvement, mainly in hydration and skin feel.


After, they continued with 1 month of testing the Sencyr Balance. Only 13 people (10 female and 3 male) were in this program. The average age was 27.8 years old. The feedback was very positive:

On day 1, only 1 person says he had skin that feels soft and cared for. On day 30, 5 people had skin felt soft and cared for.

On day 1, 9 people experienced redness. On day 30, only 4 experienced redness.


Sencyr is the first to demonstrate in a series of interventional clinical studies that carefully selected probiotics are effective to reduce spots and help to heal your skin. Also, they rebalance the skin microbiome and that’s important because when your microbiome is balanced, your skin looks and feels healthy!

You can find some pictures before and after of these subjects on the Results page. If you have any questions, feel free to contact us at Our scientific experts would be happy to answer you!